Abstract: The carbon-carbon bond is the most abundant covalent bond present in organic molecules. Though most of the efforts of the organic chemists have revolved around efficient ways to synthesize the carbon-carbon bonds, the carbon-carbon bond cleavage is almost ubiquitous in live activities and industrial production. Taking the cue from there, selective cleavage of carbon-carbon bonds has been utilized for the preparation of many complex skeletons and natural products. Recent discoveries have demonstrated that this strategy has the potential to be a general methodology in organic synthesis for the regio-, diastereo-, and enantioselective preparation of adducts. Notwithstanding the carbon-carbon bonds are the one of the least reactive functional groups, the development of these strategies has great impact on synthesis design of complex building blocks and hydrocarbons.
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