ABSTRACT: Synthesis of complex molecule from a simple starting material is a key challenge in synthesis. Enantioselective radical cyclization cascade have potential to deliver complex, densely packed polycyclic architecture with the control of 3D shape in one step. But due to high reactivity  of radicals, their enantioselectivity remains challenging and this report demonstrates the enantioselective SmI2 mediated  radical cyclization and cascade  cyclization by simple , recyclable, chiral ligand which can transform symmetrical ketoester  to complex carbocyclic product bearing multiple stereo centres. A computational  study has also been used to probe the origin of enantioselectivity.

References:Nat.Chem.9,1198 – 1204(2017): DOI:10.1038/nchem.2841