Abstract: In the last decades, Metallic nanoparticles especially Silver nanoparticles have received considerable attention due to their attractive electronic and chemical properties and their potential applications in the development of new technologies. Recent advances in the study of various silver nanomaterials and its plasmonic properties have lead their utilisation in a number of very important applications including biosensing, diagnostic imaging, and cancer diagnosis and therapy. In this presentation, I will discuss the Silver nanoparticles , its characterisation (UV-Vis, EDX, TEM and HEED) and its application in the field of biosensing. By using triangular silver (Ag) nanoparticle array, a localized surface plasmon resonance (LSPR) nanosensor was fabricated and shown to sense serum p53 protein in vitro, which is involved in head and neck squamous cell carcinoma (HNSCC). The results indicated significant differences in LSPR shifts between HNSCC patient and control. Detection and characterisation of molecular interactions on membrane surfaces is important to biological and pharmacological research. Here, silver nanocubes interfaced with glass-supported model membranes form a label-free sensor that measures protein binding to the membrane. So, in this method, static and dynamic protein/membrane binding are monitored and quantified. I will also discuss that LSPR nanosensor is shown to aid in the understanding of the interaction between amyloid β-derived diffusible ligands (ADDL) and the anti-ADDL antibody, molecules possibly involved in the development of Alzheimer’s disease. So, nanobiosensor provides a promising platform with attractive advantages for serological diagnosis or molecular diagnosis in tumour, such as HNSCC and in many diseases such as cancer and Alzhiemer.


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