Courses Offered by the Department
Department of Organic ChemistryOC 203 / CD 213
Course Name : Organic Chemistry-I
Credits : 3:0
Description
Stereochemistry and conformational analysis. Methods of deducing organic reaction mechanisms, Hammond postulate, Curtin-Hammett principle, linear free energy relationships; Hammett equation; kinetic isotope effects. Electronic effects in organic compounds, aromaticity, frontier orbital theory, steric effects;organic transformations and molecular rearrangements; reactive intermediates, classical and nonclassical carbocations, carbanions, free radicals, carbenes, nitrenes, arynes, radical ions, diradicals, concerted reactions, Woodward-Hoffman rules.
Prerequisites
Anslyn, E.V., and Dougherty, D.A., Modern Physical Organic Chemistry, University Science Books, 2006. Smith, M. B., March J., March’s Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 6th ed. Wiley, 2007. Carey F.A., and Sundberg R.J., Advanced Organic Chemistry, Part A. 5th ed. Plenum, 2007. Lowry T.M. and Richardson K.S., Mechanism and Theory in Organic Chemistry, 3rd ed, Addison-Wesley-Longman, 1998. Current literature.
Pre-requisites: Successful completion of UC201 and 205 for UG
OC 231
Credits : 3:0
Description
Amino acids, peptide synthesis, geometry and oligopeptide conformations. Non-covalent interactions, dynamism in peptides, molecular recognition, Ramachandran plot, Foldamers. Protein architecture, protein-protein interactions, protein stability. Peptide conformational analysis. Protein solubility, pKa, protein aggregates, isofolding, unfolded proteins, membrane proteins. Peptidomimetics, isosteres, folding peptides. Enzymes: mechanisms of selected enzymes, enzyme inhibitors. Important developments in current literature.
Prerequisites
Voet D and Voet J.G. Biochemistry 2nd Edition John Wiley Cysons NY, 1995. Stryer L. Biochemistry 4th Edition , WH. Freeman & Co., NY. Contemporary literature.
OC 301
Credits : 3:0
Description
Organic synthesis and total synthesis of complex natural products: Advances in C-C bond forming reactions; Olefination reactions; Olefin metathesis including alkyne metathesis; Synthesis of alkynes; Asymmetric addition of Grignard reagents, organozinc and lithium reagents to carbonyl compounds; Directed lithiation, chiral lithium reagents; alkylation of carbonyl compounds including asymmetric alkylation. Addition of organometallinc reagents to imines, Asymmetric acetate/ propionate aldol reaction. Asymmetric allylation of carbonyl compounds; Ring forming reactions, Baldwin rules; cyclopentannulations with specific application to triquinanes. Advances in carbocation rearrangements. Inverse electron demand Diels Alder reaction/ Hetero Diels Alder reaction: Application of the above in the total synthesis of natural products including natural products of contemporary interest in current literature.
Prerequisites
Wyatt P. and Warren S, Organic Synthesis, Strategy and Control,; Wiley 2007. Nicolaou, K.C., Sorensen, E.J., Classics in Total Synthesis, Wiley VCH, NY 1996. Warren S. Organic Synthesis: The Disconnection Approach, Wiley, NY, 1982. Nicolaou, K. C., Classics in Total synthesis I and II; Wiley-VCH, Weinheim 2003; Current literature
Pre-requisites: For students registered for regular PhD programme, including those coming to regular PhD programme through Int PhD and UG streams and recommendation by research supervisor
OC 302
Credits : 3:0
Description
Basics of asymmetric catalysis including energetics of reactions; Lewis acid & Lewis base catalysis; kinetic, dynamic kinetic and parallel kinetic resolution; desymmetrization reactions; mechanistic studies of asymmetric reactions: nonlinear effects, autocatalysis and autoinduction; bifunctional, dual and multifunctional catalyst systems; modern aspects of asymmetric catalysis: counterion-directed catalysis, cooperative, dual and merged catalysis, asymmetric photocatalysis etc.; applications of asymmetric catalysis.
Prerequisites
Walsh, P. J., Kozlowski, M. C., Fundamentals of Asymmetric Catalysis, University Science Books, California, 2008. Carreira, E. M., Kvaerno, L., Classics in Stereoselective Synthesis, Wiley-VCH, Weinheim, 2009. Corey, E. J., Kürti, L., Enantioselective Chemical Synthesis, Direct Book Publishing, Dallas, 2010. Current literature.
Pre-requisites: Successful completion of OC203/CD213 and CD223 (for UG and Int PhD students).
OC 303
Credits : 3:0
Description
Structures and conformational itineraries of monosaccharides; Reactions of monosaccharides: reactivity profiles at each carbon center; ring expansions and contractions; reactions at anomeric carbon and epimeric carbons; deoxy sugars; anhydrosugars; protecting group methods; chemical and enzymatic glycosylations to oligosaccharides; glycosidic bond stabilities; naturally-occurring oligo- and polysaccharides and their conformations; chiral auxiliaries and modifications of sugars to carbocycles and heterocycles; aspects of animal and plant polysaccharides, glycoproteins, proteoglycans and glycosaminoglycans; selected natural product synthesis originating from a sugar scaffold.
Prerequisites
Monosaccharides: Their chemistry and their roles in natural products, P. Collins and R. Ferrier, John Wiley & Sons Ltd., Chichester, 1998 2. Carbohydrates: The essential molecules of life, R. V. Stick, S. J. Williams, Elsevier, Oxford, 2001 3. Organic synthesis with carbohydrates, G.-J. Boons, K. J. Hale, Blackwell Science, Inc., Malden, 2000
Pre-requisites: Regular PhD students; Int PhD students: Completion of CD213 and CD223 courses; UG students: Completion of UC205, CD213 and CD223
OC 304
Course Name : Physical Methods of Structure Elucidation
Credits : 3:0
Description
Physical Methods of Structure Elucidation Structure elucidation of organic compounds using physical methods: Principles underlying the following techniques and their applications in organic chemistry will be discussed. Ultraviolet, Visible, Infrared, NMR (1H and 13C) Spectroscopy, and Mass Spectrometry.
CD 215
Credits : 0:4
Description
Common organic transformations such as esterification, Diels-Alder reaction, oxidation-reduction, Grignard reaction, etc. Isolation and purification of products by chromatographic techniques, characterization of purified products by IR and NMR spectroscopy. Synthesis of coordination complexes, preparation of compounds of main group elements, synthesis of organo-metallic complexes. Physico-chemical characterization of these compounds by analytical and spectroscopic techniques
Prerequisites
In consultation with the assigned faculty
CD 241
Credits :0:14
Description
Research project in consultation with Ph. D. Supervisor, covering August and January terms.
Prerequisites
In consultation with the assigned faculty
UC 206
Credits :2:1
Description
Nomenclature of organic compounds: alkanes, alkenes and alkynes; structure and reactivity. Concept of aromaticity; organic reactions – Addition reactions; Elimination reactions; substitution reactions and rearrangements. Organic reaction mechanisms; reaction intermediates and their characterization. Introduction to stereochemistry.
UC 205
Credits :2:0
Description
Acids and bases: definitions, pKa, pKaH, effect of structure on acid/base strength, kinetic & thermodynamic acidity, general & specific acid/base catalysis; Reactions of alkenes and alkynes: addition of halogens, hydrogen halides & interhalogen compounds, halolactonization – Baldwin’s rule & Thorpe-Ingold effect, hydration, epoxidation, dihydroxylation, ozonolysis, diol cleavage, carbenes and their reactions with olefins, hydrogenation; Reactions of carbonyl compounds: addition to carbonyls, reductions, rearrangements & their applications, oxidations, C–C bond forming reactions involving carbonyls, Cram’s rule, Felkin-Anh model; Introduction to pericyclic reactions: cycloadditions, elctrocyclic reactions, FMO theory and Woodward-Hoffmann rules.
Prerequisites
Norman, R. O. C. and Coxon, J. M.; Principles of Organic Synthesis, 3rd Ed., (1993); Carruthers, W. and Coldham, I.; Modern Methods of Organic Synthesis, 4th Ed., Cambridge University Press, (2004); Clayden, J.; Greeves, N.; Warren, S. And Wothers, P.; Organic Chemistry, Oxford University Press, (2000); Carey, F. A. and Sundberg, R. J.; Advanced Organic Chemistry, Part A & Part B, 5th Ed., Springer, (2007).
CD 223
Credits :3:0
Description
Synthetic methods, methodologies and mechanisms in reductions, oxidations of carbon-carbon and carbon-heteroatom bonds; Carbon-carbon bond-forming methodologies through ionic, radical, concerted and organometallic reaction mechanisms; Approaches to multi-step synthesis with examples of chosen natural and un-natural product synthesis, through anti-thetic analysis and logical synthesis.
Prerequisites
H. O. House, Modern synthetic methods, W. A. Benjamin, Inc., 1972
M. B. Smith, Organic synthesis, McGraw-Hill, 2002
E. J. Corey and Chung, Logic in chemical synthesis, John-Wiley & Sons, 1989
Chosen primary literature and review articles
Prerequisite: UG students having completed UC 205, OC 203/CD213; Chemistry major students