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Kavirayani R. Prasad

by | May 6, 2017 | Students |

 Professor
Department of Organic Chemistry
Indian Institute of Science, Bangalore 560012,INDIA
Tel: 2293-2524; Fax: 23600529
Email: prasad@iisc.ac.in

Education:

BSc:      Andhra University,  Visakhapatnam (1989)
MSc:    Sri Krishnadevraya Univesrity, Anantapur (1991)
PhD:     National Chemical Laboratory, Pune 1997

Alexander von Humboldt Foundation Post-Doctoral Fellow
Organisch-Chemisches Institut, Universität Münster, Germany 1998-2000

Post-Doctoral Fellow
Department of Chemistry, Temple University, Philadelphia, USA 2000-2003

Professional:

07/2014- Present Professor
Department of Organic Chemistry, Indian Institute of Science Bangalore, 560012, India
08/2008-07/2014 Associate Professor
Department of Organic Chemistry, Indian Institute of Science Bangalore, 560012, India
11/2003-08/2008  Assistant Professor
Department of Organic Chemistry, Indian Institute of Science Bangalore, 560012, India
03/2003- 10/2003 Research Scientist
Praecis Pharmaceuticals Inc (presently Glaxo Smith Kline) Waltham,MA.USA
  • Associate Editor; Organic Letters, A premier journal in organic chemistry published by the American Chemical Society
  • Fellow, Indian Academy of Sciences, 2015
  • Shanti Swarup Bhatnagar prize for chemical Sciences, 2014
  • Prof. N. S. Narasimhan Endowment Lecture Award, University of Pune 2013
  • Rajib Goyal Prize, 2012
  • NASI (National Academy of Sciences)-SCOPUS Young Scientist award
  • Swarnajayanthi fellowship of the Department of Science and Technology, New Delhi 2006
  • Prof. ASR Anjaneyulu Endowment lectureship of the Indian Chemical Society 2007
  • Alexander von Humboldt foundation post-doctoral fellowship, Federal Republic of Germany 1998-2000
The core theme of Prof. Prasad’s research is the total synthesis of complex natural products of therapeutic significance with an emphasis on development of asymmetric synthetic strategies/ methodologies en route to the natural products. Some of the recent investigations include the total synthesis of complex macrolactones such as palmerolides, arenicolides, complex indole alkaloids such as strychnine and triquinane natural products. Prof. Prasad’s group is also developing synthetic strategies utilizing chiral sulfinimines and their application in the synthesis of bio-active alkaloids. The group also has collaborative program on the bio-activity profile of natural products and analogues with a particular interest in p53 protein; the protein responsible for the control of many cellular processes.

Synthesis of the Macrolactone Core of the Revised Structure of Palmerolide C . Vaithegi, K.; Pawar, A. B.; Prasad, K. R. Tetrahedron 2021, 77, 131768.

Addition of Lithium Anion of (Acetylmethylene)triphenylphosphorane to Nonracemic Sulfinimines: Total Synthesis of (+)-241D and Formal Total Synthesis of (+)-Preussin. Khandare, S. P.; Reddy, P. O.; Prasad, K. R. Org. Lett. 2020, 22, 7273-7277

Stereoselective Synthesis of β-Amino Ynones by the Addition of Alkynones to Nonracemic Sulfinimines: Formal Total Synthesis of l-Xylo and l-Arabino Phytosphingosines Reddy, P. O.; Reddy, A. A. Prasad, K. R. J. Org. Chem. 2020, 85, 2743-2751

Stereoselective Addition of a Lithium Anion of 1,1-Diphenyl-2-aza-pentadiene to Sulfinimines: Application to the Synthesis of (−)-Epiquinamide. Uphade, M. B.; Reddy, A. A.; Khandare, S. P.; Prasad, K. R.    Org. Lett. 2019, 21, 9109-9113.

Furan Oxidation Strategy for the total synthesis of Macrolactone analogue of migrastatin.    Airan, Y.; Prasad, K. R. J. Org. Chem. 2019, 84, 14974-14979